19
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T26046 | Razoxane | Topoisomerase | |
Razoxane is used as an antimitotic agent with immunosuppressive properties. | |||
T6683 | STF-62247 | STF 62247 | Estrogen/progestogen Receptor , Autophagy |
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. | |||
T2456 | Tivozanib | AV-951,KRN951 | VEGFR , PDGFR , Ephrin Receptor |
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. | |||
T24818 | Sparfosic Acid | NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131 | Apoptosis |
Sparfosic Acid (Acide sparfosique) is an aspartate carbamoyltransferase inhibitor with antitumor activity and can be used to study advanced renal cell carcinoma. | |||
T16777 | ROC-325 | Apoptosis , Autophagy | |
ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity. | |||
T77810 | XPW1 | CDK | |
XPW1 is a new potent and selective CDK9 inhibitor with antitumour activity that transcriptionally inhibits the DNA repair process in ccRCC cells.XPW1 can be used to study clear cell renal cell carcinoma. | |||
T16679 | Belzutifan | PT2977,MK-6482 | HIF |
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,... | |||
T1916 | Apitolisib | RG 7422,GNE 390,GDC-0980 | Apoptosis , PI3K , mTOR |
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce... | |||
T76828 | Sonepcizumab | LT 1009 | LPL Receptor |
Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell carcinoma (mRCC) to prevent eye scarring after glaucoma fi... | |||
T63505 | Tivozanib hydrochloride hydrate | ||
Tivozanib hydrochloride hydrate is a selective, potent, orally active VEGFR tyrosine kinase inhibitor that acts on VEGFR-1 (IC50: 0.21 nM), VEGFR-2 (IC50: 0.16 nM), and VEGFR-3 (IC50: 0.24 nM). Tivozanib hydrochloride hy... | |||
T28408 | Phosphostim Sodium | IPH1101,Phosphostim,IPH 1101,IPH-1101 | |
Phosphostim, a gamma9deta2 T lymphocytes agonist, is used potentially for the treatment of renal cell carcinoma, HCV infection. | |||
T31058 | CP-461 free base | CEL031,CP461,UNII-824ZMS3BGL,CP-461,OSI-461 | |
CP-461 (OSI-461) is a pde2a / 5A inhibitor, which may be used in the treatment of renal cell carcinoma, prostate cancer, and Crohn's disease. | |||
T74597 | Zifcasiran | ||
Zifcasiran, a hypoxia-inducible factor (HIF) synthesis reducer, exhibits antitumor activities and is utilized in advanced renal cell carcinoma research [1] [2]. | |||
T61442 | HIF-1/2α-IN-1 | ||
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea... | |||
T81704 | Naptumomab | ||
Naptumomab, a tumor-targeting superantigen (TTS), is a fusion protein that activates the immune system to recognize and eradicate tumor cells. It shows promise in researching refractory solid tumors, including renal cell... | |||
T36859 | C16 Globotriaosylceramide (d18:1/16:0) | C16 Globotriaosylceramide (d18:1/16:0) | |
C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raj... | |||
T76803 | Elsilimomab | ||
Elsilimomab (B-E8), an IgG1 monoclonal antibody targeting interleukin-6 (IL-6), exhibits a dissociation constant (K D) of 22 pM and an inhibitory concentration (IC 50) of 1.4 nM. It is applicable in researching multiple ... | |||
T63008 | PERK-IN-5 | ||
PERK-IN-5 is a highly selective, potent, orally active inhibitor of the protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) that acts on PERK (IC50: 2 nM) and p-eIF2α (IC50: 9 nM). PERK-IN-5 significantly inhi... | |||
T36439 | Gramicidin A | Antibacterial , HIF , Parasite | |
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t... |